When memory mapping a file, it is possible to run out of address space in 32-bit VM. This happens even if the file is mapped in smallish chunks and those ByteBuffers are no longer reachable. The reason is that GC never kicks in to free the buffers:

===
import java.io.RandomAccessFile;
import java.nio.ByteBuffer;
import java.nio.channels.FileChannel;
import static java.nio.channels.FileChannel.MapMode.READ_ONLY;

public class Test {
    
    public static void main(String[] args) throws Exception {
        String name = args[0];
        FileChannel channel = new RandomAccessFile(name, "r").getChannel();
        long size = channel.size();
        System.out.println("File " + name + " is " + size + " bytes large");
        long ofs = 0;
        int chunksize = 512 * 1024 * 1024;
        while (ofs < size) {
            int n = (int)Math.min(chunksize, size - ofs);
            ByteBuffer buffer = channel.map(READ_ONLY, ofs, n);
            System.out.println("Mapped " + n + " bytes at offset " + ofs);
            ofs += n;
        }
        channel.close();
    }
}
===

java -showversion -verbose:gc Test large.iso
java version "1.6.0-beta2"
Java(TM) SE Runtime Environment (build 1.6.0-beta2-b81)
Java HotSpot(TM) Client VM (build 1.6.0-beta2-b81, mixed mode)

File large.iso is 6603407360 bytes large
Mapped 536870912 bytes at offset 0
Mapped 536870912 bytes at offset 536870912
Mapped 536870912 bytes at offset 1073741824
Mapped 536870912 bytes at offset 1610612736
Mapped 536870912 bytes at offset 2147483648
Mapped 536870912 bytes at offset 2684354560
Mapped 536870912 bytes at offset 3221225472
Exception in thread "main" java.io.IOException: Not enough space
        at sun.nio.ch.FileChannelImpl.map0(Native Method)
        at sun.nio.ch.FileChannelImpl.map(FileChannelImpl.java:742)
        at Test.main(Test.java:18)