Steps to reproduce:
1) Install jre8u45 and jre8u60
2) Uninstall jre8u60
3) If browser would not able to open applet like plugin is not installed, bug is reproducible

Note: Uninstall jre8u45 and then reinstall jre8u45 cannot fix it. It looks like another issue.

4) Uninstall jre8u45 and reinstall jre8u45
5) Open any signed applet like http://java.com/en/download/installed8.jsp or http://mydesktop.oracle.com
6) If applet/application is blocked like they are self-signed, bug is reproducible.
7) Run javaws, got error: The system cannot find the file C:\ProgramData\Oracle\Java\javapath\javaws.exe
8) Also cannot open jcp from control panel.

There are the exception:
com.sun.deploy.security.BlockedException: Your security settings have blocked a self-signed application from running
at com.sun.deploy.security.BlockedDialog.show(Unknown Source)
at com.sun.deploy.security.TrustDecider.validateChain(Unknown Source)
at com.sun.deploy.security.TrustDecider.isAllPermissionGranted(Unknown Source)
at sun.plugin2.applet.Plugin2ClassLoader.isTrustedByTrustDecider(Unknown Source)
at sun.plugin2.applet.Plugin2ClassLoader.getPermissions(Unknown Source)
at sun.plugin2.applet.Applet2ClassLoader.getPermissions(Unknown Source)
at java.security.SecureClassLoader.getProtectionDomain(Unknown Source)
at java.security.SecureClassLoader.defineClass(Unknown Source)
at java.net.URLClassLoader.defineClass(Unknown Source)
at sun.reflect.NativeMethodAccessorImpl.invoke0(Native Method)
at sun.reflect.NativeMethodAccessorImpl.invoke(Unknown Source)
at sun.reflect.DelegatingMethodAccessorImpl.invoke(Unknown Source)
at java.lang.reflect.Method.invoke(Unknown Source)
at sun.plugin2.applet.Plugin2ClassLoader.defineClassHelper(Unknown Source)
at sun.plugin2.applet.Plugin2ClassLoader.access$100(Unknown Source)
at sun.plugin2.applet.Plugin2ClassLoader$2.run(Unknown Source)
at sun.plugin2.applet.Plugin2ClassLoader$2.run(Unknown Source)
at java.security.AccessController.doPrivileged(Native Method)
at sun.plugin2.applet.Plugin2ClassLoader.findClassHelper(Unknown Source)
at sun.plugin2.applet.Applet2ClassLoader.findClass(Unknown Source)
at sun.plugin2.applet.Plugin2ClassLoader.loadClass0(Unknown Source)
at sun.plugin2.applet.Plugin2ClassLoader.loadClass(Unknown Source)
at sun.plugin2.applet.Plugin2ClassLoader.loadClass0(Unknown Source)
at sun.plugin2.applet.Plugin2ClassLoader.loadClass(Unknown Source)
at sun.plugin2.applet.Plugin2ClassLoader.loadClass(Unknown Source)
at java.lang.ClassLoader.loadClass(Unknown Source)
at sun.plugin2.applet.Plugin2ClassLoader.loadCode(Unknown Source)
at sun.plugin2.applet.Plugin2Manager.initAppletAdapter(Unknown Source)
at sun.plugin2.applet.Plugin2Manager$AppletExecutionRunnable.run(Unknown Source)
at java.lang.Thread.run(Unknown Source)