Prerequisites: Seperate Camera on a SubScene:

The MouseEvents report always the same values even if the camera translates and shows a different part of the scene. Minimal Code:

    @Override
    public void start(Stage primaryStage) throws Exception{
        Pane rootOne = new Pane();
        rootOne.getChildren().add(new Circle(30, Color.RED));
        SubScene subScene = new SubScene(rootOne, 300, 270);
        Group root = new Group(subScene);
        Scene scene = new Scene(root, 300, 275);
        final Camera camera = new ParallelCamera();
        subScene.setCamera(camera);

        scene.setOnMousePressed(event -> {
            System.out.println(event.getX() + " " + event.getSceneX() + " " + event.getScreenX());
            camera.setTranslateX(camera.getTranslateX() - 30);
        });
        primaryStage.setScene(scene);
        primaryStage.show();
    }

Stay with the mouse on the same spot and click. The Camera translates, and with it the objects but the MouseEvent reports the same coordinates on every field.