As title. Run the test below to reproduce the issue. The Popup has setHideOnEscape(true).

import javafx.application.Application;
import javafx.event.ActionEvent;
import javafx.event.EventHandler;
import javafx.geometry.Insets;
import javafx.geometry.Point2D;
import javafx.scene.Group;
import javafx.scene.Scene;
import javafx.scene.control.Button;
import javafx.scene.control.CheckBox;
import javafx.scene.control.Label;
import javafx.scene.control.TextField;
import javafx.scene.layout.Background;
import javafx.scene.layout.VBox;
import javafx.stage.Popup;
import javafx.stage.Stage;

public class TextFieldInPopupBug {
    public static class ComboBoxSetItemsBug extends Application {

        public static void main(String[] args) {
            launch(args);
        }

        @Override
        public void start(Stage stage) {
            final Button button = new Button("Click to Show Popup");

            button.setOnAction(new EventHandler<ActionEvent>() {
                @Override
                public void handle(ActionEvent event) {
                    Popup popup = new Popup();
                    popup.setAutoHide(true);
                    popup.setHideOnEscape(true);
                    VBox box = new VBox(10, new TextField("Focus on this one, ESCAPE doesn't work"), new CheckBox("Focus on this one, ESCAPE works"));
                    box.setPadding(new Insets(10));
                    popup.getContent().addAll(box);
                    Point2D p = button.localToScreen(0, 0);
                    popup.show(button, p.getX(), p.getY() + button.getHeight());
                }
            });

            VBox vbox = new VBox(6, button, new Label("Clicking on the button to show a popup. Focus on the text field and press ESCAPE. The popup doesn't hide." +
                    "\nYou can read comment in the file for more information"));
            vbox.setPadding(new Insets(10));

            Scene scene = new Scene(new Group());
            stage.setTitle("TextField in Popup Bug");
            ((Group) scene.getRoot()).getChildren().addAll(vbox);
            stage.setScene(scene);
            stage.show();
        }
    }
}