I'm working with big images (9683x5800) and get the following exception:

java.lang.NullPointerException
        at com.sun.prism.impl.BaseResourceFactory.clearTextureCache(BaseResourceFactory.java:47)
        at com.sun.prism.impl.BaseResourceFactory.getCachedTexture(BaseResourceFactory.java:102)
        at com.sun.prism.image.CachingCompoundImage.getTile(CachingCompoundImage.java:27)
        at com.sun.prism.image.CompoundCoords.draw(CompoundCoords.java:74)
        at com.sun.javafx.sg.prism.NGImageView.renderContent(NGImageView.java:127)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:203)
        at com.sun.javafx.sg.prism.NGImageView.doRender(NGImageView.java:97)
        at com.sun.javafx.sg.prism.NGImageView.doRender(NGImageView.java:20)
        at com.sun.javafx.sg.BaseNode.render(BaseNode.java:1164)
        at com.sun.javafx.sg.prism.NGGroup.renderContent(NGGroup.java:204)
        at com.sun.javafx.sg.prism.NGRegion.renderContent(NGRegion.java:420)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:203)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:39)
        at com.sun.javafx.sg.BaseNode.render(BaseNode.java:1164)
        at com.sun.javafx.sg.prism.NGGroup.renderContent(NGGroup.java:204)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:203)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:39)
        at com.sun.javafx.sg.BaseNode.render(BaseNode.java:1164)
        at com.sun.javafx.sg.prism.NGGroup.renderContent(NGGroup.java:204)
        at com.sun.javafx.sg.prism.NGRegion.renderContent(NGRegion.java:420)
        at com.sun.javafx.sg.prism.NGNode.renderForClip(NGNode.java:445)
        at com.sun.javafx.sg.prism.NGNode.renderRectClip(NGNode.java:336)
        at com.sun.javafx.sg.prism.NGNode.renderClip(NGNode.java:362)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:195)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:39)
        at com.sun.javafx.sg.BaseNode.render(BaseNode.java:1164)
        at com.sun.javafx.sg.prism.NGGroup.renderContent(NGGroup.java:204)
        at com.sun.javafx.sg.prism.NGRegion.renderContent(NGRegion.java:420)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:203)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:39)
        at com.sun.javafx.sg.BaseNode.render(BaseNode.java:1164)
        at com.sun.javafx.sg.prism.NGGroup.renderContent(NGGroup.java:204)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:203)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:39)
        at com.sun.javafx.sg.BaseNode.render(BaseNode.java:1164)
        at com.sun.javafx.sg.prism.NGGroup.renderContent(NGGroup.java:204)
        at com.sun.javafx.sg.prism.NGRegion.renderContent(NGRegion.java:420)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:203)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:39)
        at com.sun.javafx.sg.BaseNode.render(BaseNode.java:1164)
        at com.sun.javafx.sg.prism.NGGroup.renderContent(NGGroup.java:204)
        at com.sun.javafx.sg.prism.NGRegion.renderContent(NGRegion.java:420)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:203)
        at com.sun.javafx.sg.prism.NGNode.doRender(NGNode.java:39)
        at com.sun.javafx.sg.BaseNode.render(BaseNode.java:1164)
        at com.sun.javafx.tk.quantum.ViewPainter.doPaint(ViewPainter.java:118)
        at com.sun.javafx.tk.quantum.AbstractPainter.paintImpl(AbstractPainter.java:184)
        at com.sun.javafx.tk.quantum.PresentingPainter.run(PresentingPainter.java:73)
        at java.util.concurrent.Executors$RunnableAdapter.call(Executors.java:471)
        at java.util.concurrent.FutureTask$Sync.innerRunAndReset(FutureTask.java:351)
        at java.util.concurrent.FutureTask.runAndReset(FutureTask.java:178)
        at com.sun.prism.render.RenderJob.run(RenderJob.java:37)
        at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1110)
        at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:603)
        at com.sun.javafx.tk.quantum.QuantumRenderer$PipelineRunnable.run(QuantumRenderer.java:98)
        at java.lang.Thread.run(Thread.java:722)

I take a look at the source code and noticed that

        Collection<Texture> texAll = texCache.values();

can contain null values as per WeakHashMap definition. Moreover, they are added in getCachedTexture() method:

            tex = createTexture(image, Usage.DEFAULT, allowPad);
            if (tex == null) {
                clearTextureCache();
                tex = createTexture(image, Usage.DEFAULT, allowPad);
            }
            if (tex != null) {
                tex.setLastImageSerial(serial);
            }
            
            texCache.put(image, tex);

so it is necessary to check for null as following:

        for (Texture i : texAll) {
            if (i != null) {
                i.dispose();
            }
        }