JavaFX applets can not be launched on Mac OS X 10.7.4/ Safari 6 via fiile:/// .
Applet resources are all locally (no network access). The JavaFX samples can be used to reproduce the issue consistently

*** Tested Configuration:
- Mac OS X 10.7.4
- Safari 6.0 (7536.25)
- jre 7u6-b21 promoted build
- javafx_samples-2_2_0-beta-b19 samples

*** Steps to reproduce:
0) Install jre 7u6-b21
1) Get the JavaFX sample bundle and unzip everything to the test machine
http://jre.us.oracle.com/java/re/javafx/2.2/promoted/beta/b19/bundles/macosx-x86_64/javafx_samples-2_2_0-beta-b19-macosx-x86_64-25_jul_2012.zip
2) Using Safari 6 to invoke one of the JavaFX samples from the step#2 (e.g BrickBreaker.html, Ensemble.html) as:

file:///<path-to-the-unzipped-javafx-sample>/BrickBreaker.html


If you see the applet fails to load, the loading logo spinning forever, the issue is reproducible