There are numerous places in the VM enumerating the set of classes that define signature polymorphic methods:

  static bool has_member_arg(Symbol* klass, Symbol* name) {
    if ((klass == vmSymbols::java_lang_invoke_MethodHandle() ||
         klass == vmSymbols::java_lang_invoke_VarHandle()) &&

vmIntrinsics::ID MethodHandles::signature_polymorphic_name_id(Klass* klass, Symbol* name) {
  if (klass != NULL &&
      (klass->name() == vmSymbols::java_lang_invoke_MethodHandle() ||
       klass->name() == vmSymbols::java_lang_invoke_VarHandle())) {

bool MethodHandles::is_method_handle_invoke_name(Klass* klass, Symbol* name) {
  if (klass == NULL)
    return false;
  // The following test will fail spuriously during bootstrap of MethodHandle itself:
  // if (klass != SystemDictionary::MethodHandle_klass())
  // Test the name instead:
  if (klass->name() != vmSymbols::java_lang_invoke_MethodHandle() &&
      klass->name() != vmSymbols::java_lang_invoke_VarHandle()) {

Each of these locations need to be updated when/if this set changes. It's easy to miss a few (see JDK-8164214, JDK-8163962). This repetition should be cut down to as few places as possible, ideally all located in methodHandles.[ch]pp.