It is currently not possible to run a manual JTREG test via make run-test:
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 make run-test TEST="open/test/jdk/jdk/nio/zipfs/TestLocOffsetFromZip64EF.java" JTREG="OPTIONS=-manual"
Building target 'run-test' in configuration 'macosx-x64'
Creating jdk image
Creating CDS archive for jdk image
Creating CDS-NOCOOPS archive for jdk image
Running tests using JTREG control variable 'OPTIONS=-manual'
Test selection 'open/test/jdk/jdk/nio/zipfs/TestLocOffsetFromZip64EF.java', will run:
* jtreg:open/test/jdk/jdk/nio/zipfs/TestLocOffsetFromZip64EF.java

Running test 'jtreg:open/test/jdk/jdk/nio/zipfs/TestLocOffsetFromZip64EF.java'
Error: Invalid option combination: -automatic and -manual
Usage:
         jtreg options... tests...

Tests can be given as files or folders containing test files, or by means of
test groups. Long lists of options and tests may be encapsulated in "at-files".

For brief details about a topic, use "-help <term> ...". The argument <term> is
a command option or other word related to the topic. Use "-help all" to show all
of the help entries.

Information is available for the following topics.

Verbose Options
                These options control the amount of output written to the
                console while running tests

Documentation Options
                Options for additional documentation

General Options

Timeout Options
                These options control the behavior when tests run longer than
                their specified timeout value.
Agent Pool Options
                Options to configure the size of the pool of VMs used to execute
                tests in agent mode.
Test Selection Options
                These options can be used to refine the set of tests to be
                executed.

Test Mode Options
                Each test consists of a series of steps, called actions. The
                jtreg harness provides different modes, which determine the JVM
                to use to execute each action. The default is to run each action
                in a new JVM.

JDK-related Options
                By default, tests will be run using the default JVM in the test
                JDK. You can pass all applicable JVM options via using
                -vmoption; in addition, many common JVM options are also
                supported directly. For full details of any option, consult the
                documentation for that version of the JDK, or try using "java
                -help" or "java -X". If an option is not applicable to a
                particular platform or JDK release, it will be rejected.

JCov-related options
                jtreg provides support for using the jcov code coverage tool to
                gather code coverage information while tests are being run. At a
                minimum, you must specify where to find the classes to be
                monitored, and where to find source code for those classes. For
                more details, see the JCov User Guide and the command line help
                for the jcov programs: Instr, Grabber, GrabberManager and
                RepGen.

Tests Specifying collections of tests.


Copyright (c) 1999, 2019, Oracle and/or its affiliates. All rights reserved.
Use is subject to license terms.

Finished running test 'jtreg:open/test/jdk/jdk/nio/zipfs/TestLocOffsetFromZip64EF.java'
Test report is stored in /Users/ljanders/Documents/git-workspaces/jdk/build/macosx-x64/test-results/jtreg_open_test_jdk_jdk_nio_zipfs_TestLocOffsetFromZip64EF_java

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It would be beneficial to provide this support to make it easier for developers and to avoid a separate process for running JTREG tests