jniHandles.hpp is included by about 800 out of 1000 HotSpot .o files. Most of these are transitively included from these header files, which don't actually need to include jniHandles.hpp.

ci/ciBaseObject.hpp
ci/ciMetadata.hpp
ci/ciObject.hpp
classfile/moduleEntry.hpp
gc/shared/gcVMOperations.hpp
jvmci/jvmciJavaClasses.hpp
runtime/thread.hpp
services/threadService.hpp

Fixing these headers reduces the number of .o files that include jniHandles.hpp to 145