The signature polymorphic methods in VarHandle need special casing similar to invoke/invokeExact in MethodHandle. The relevant section of the Java SE API specification says that an UnsupportedOperationException is thrown when invoking such a method using reflections. The same wording is used in MethodHandle.
(https://github.com/openjdk/jdk/blob/d7b941640638b35f9ac1ef11cd6bf6ccb795c29a/src/java.base/share/classes/java/lang/invoke/VarHandle.java#L435-L442)

However, the VarHandle methods currently throw an UnsatisfiedLinkError instead.